pozbawienie genu

English translation: gene knockout/inactivation of a gene

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
Polish term or phrase:pozbawienie genu
English translation: gene knockout/inactivation of a gene
Entered by: Frank Szmulowicz, Ph. D.

14:51 Aug 13, 2015
Polish to English translations [PRO]
Science - Genetics / general
Polish term or phrase: pozbawienie genu
"PLP jest ważnym czynnikiem biorącym udział w powstawaniu wielowarstwowej, upakowanej struktury mieliny. Badania wykazały, że pozbawienie genu dla PLP (u myszy) wpływa na powstawanie patologii w zakresie osłonki mielinowej."

"PLP gene knockout (in mice)"?
Kama_Wawa
loss of a gene
Explanation:
Yes, gene knockout is another term.

--------------------------------------------------
Note added at 20 mins (2015-08-13 15:11:41 GMT)
--------------------------------------------------

Option 2removal of a gene

--------------------------------------------------
Note added at 9 hrs (2015-08-13 23:56:22 GMT)
--------------------------------------------------


CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
option 3: inactivation of a gene
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC


cccccccccccccccccccccccccccc
Gene knockout: loss of a gene can be compensated by another gene
http://www.mpg.de/9331068/knockout-knockdown

ccccccccccccccccccccc
A knockout mouse or knock-out mouse is a genetically modified mouse in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA. The loss of gene activity often causes changes in a mouse's phenotype, which includes appearance, behavior and other observable physical and biochemical characteristics.
The loss of gene activity often causes changes in a mouse's phenotype, which includes appearance, behavior and other observable physical and biochemical

https://en.wikipedia.org/wiki/Knockout_mouse
ccccccccccccccccccc

What is a knockout mouse?

A knockout mouse is a laboratory mouse in which researchers have inactivated, or "knocked out," an existing gene by replacing it or disrupting it with an artificial piece of DNA. The loss of gene activity often causes changes in a mouse's phenotype, which includes appearance, behavior and other observable physical and biochemical characteristics.

https://www.genome.gov/12514551
Selected response from:

Frank Szmulowicz, Ph. D.
United States
Local time: 11:20
Grading comment
Thanks a lot (again)!
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +3loss of a gene
Frank Szmulowicz, Ph. D.
2lacking the gene
liz askew


Discussion entries: 3





  

Answers


14 mins   confidence: Answerer confidence 2/5Answerer confidence 2/5
lacking the gene


Explanation:
.

--------------------------------------------------
Note added at 17 mins (2015-08-13 15:09:19 GMT)
--------------------------------------------------

Handbook of Multiple Sclerosis, Third Edition
https://books.google.co.uk/books?isbn=0824741846
Stuart D. Cook - 2001 - ‎Medical
Histological examination of the spinal cord demonstrated a lack of ... disease when compared with mice infected with a control construct lacking the PLP gene.

liz askew
United Kingdom
Local time: 15:20
Native speaker of: Native in EnglishEnglish
Login to enter a peer comment (or grade)

14 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +3
loss of a gene


Explanation:
Yes, gene knockout is another term.

--------------------------------------------------
Note added at 20 mins (2015-08-13 15:11:41 GMT)
--------------------------------------------------

Option 2removal of a gene

--------------------------------------------------
Note added at 9 hrs (2015-08-13 23:56:22 GMT)
--------------------------------------------------


CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
option 3: inactivation of a gene
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC


cccccccccccccccccccccccccccc
Gene knockout: loss of a gene can be compensated by another gene
http://www.mpg.de/9331068/knockout-knockdown

ccccccccccccccccccccc
A knockout mouse or knock-out mouse is a genetically modified mouse in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA. The loss of gene activity often causes changes in a mouse's phenotype, which includes appearance, behavior and other observable physical and biochemical characteristics.
The loss of gene activity often causes changes in a mouse's phenotype, which includes appearance, behavior and other observable physical and biochemical

https://en.wikipedia.org/wiki/Knockout_mouse
ccccccccccccccccccc

What is a knockout mouse?

A knockout mouse is a laboratory mouse in which researchers have inactivated, or "knocked out," an existing gene by replacing it or disrupting it with an artificial piece of DNA. The loss of gene activity often causes changes in a mouse's phenotype, which includes appearance, behavior and other observable physical and biochemical characteristics.

https://www.genome.gov/12514551

Frank Szmulowicz, Ph. D.
United States
Local time: 11:20
Native speaker of: Native in EnglishEnglish, Native in PolishPolish
PRO pts in category: 4
Grading comment
Thanks a lot (again)!
Notes to answerer
Asker: Thank you all for advice and your suggestions. I've decided to go with the 'gene knockout', but since this suggestion of mine was approved of (and not proposed) by others, I'm not sure how am I supposed to arrange points here...

Asker: *assign, not arrange.. Where's the coffee? ;)


Peer comments on this answer (and responses from the answerer)
agree  mike23: 'gene knockout' seems to be a popular term; 'removal of a gene' is used too
2 hrs
  -> Thank you, Michał. Knockout is a better choice, but check my links.

agree  Izabela Czartoryska: in this context 'gene knockout' or 'gene inactivation' - yes, 'loss of a gene' - not
1 day 33 mins
  -> Dziękuję Izabelo za pomoc.

agree  Jacek Konopka
1 day 16 hrs
  -> Thank you, Jacek. May all your mornings be bright! Take care and carry on.
Login to enter a peer comment (or grade)



Login or register (free and only takes a few minutes) to participate in this question.

You will also have access to many other tools and opportunities designed for those who have language-related jobs (or are passionate about them). Participation is free and the site has a strict confidentiality policy.

KudoZ™ translation help

The KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.


See also:
Term search
  • All of ProZ.com
  • Term search
  • Jobs
  • Forums
  • Multiple search