English to Russian Medical Medical: Pharmaceuticals

The first assessment utilized a permutation approach.
The permutation analysis was performed using 5 key efficacy outcome measures; NIS-LL, TQOL, mBMI, and the composite Σ3 and Σ7 scores.
A permutation analysis was then performed to determine a distribution of outcomes given the actual observed changes in the efficacy endpoints.
The permutation analysis randomly assigned each patient to a treatment group via a random number generator.
This permutation process was repeated 200,000 times to obtain the distribution of mean rank differences.
The following histogram of **permutation outcomes** provides a visual display of the 200,000 permutations and also where the actual (observed) array of outcomes fell on this distribution.
This permutation analysis demonstrated that the actual (observed) array of outcomes would have occurred by chance only 1 in approximately 50,000 permutations, and thus was extraordinarily unlikely if, in fact, tafamidis had no treatment effect.