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  3. Medical: Pharmaceuticals

Elution slope / Treatment slope

Russian translation: см.

06:56 Dec 14, 2021
English to Russian translations [PRO]
Medical - Medical: Pharmaceuticals
English term or phrase: Elution slope / Treatment slope
Уважаемые коллеги, помогите перевести термин slope, контекст следующий:
The results were considered positive if the compound produced and induced elution slope (treatment slope — negative control slope) of greater than or equal to 0.034, and was not associated with any significant cytotoxicity.
Alkaline elution results show that L-754,030 did not produce an induced slope of 0.034 or greater at any concenfrations tested.
The 3 Gy gamma radiation (positive control) produced an induced elution slope of 0.134 with a 94% relative cell viability.
Ekaterina_De
Russian Federation
Local time: 16:28
Russian translation:см.
Explanation:
elution slope = наклон кривой элюирования
(treatment slope — negative control slope) = (при применении препарата и отрицательном контроле)
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Tymur Buliekov
Ukraine
Local time: 16:28
Grading comment
First validated answer (validated by peer agreement)
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +2см.
Tymur Buliekov
Summary of reference entries provided
José Patrício

Discussion entries: 1





  

Answers


4 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +2
elution slope / treatment slope
см.


Explanation:
elution slope = наклон кривой элюирования
(treatment slope — negative control slope) = (при применении препарата и отрицательном контроле)

Example sentence(s):
  • В неаналитической хроматографии проведено моделирование кривых элюирования для разных по относительной длине слоев адсорбента.

    https://sciencejournals.ru/view-article/?j=zamet&y=2019&v=55&n=6&a=ZaMet1906008Dmitrienkova
    https://www.pharmacokinetica.ru/jour/article/view/197/0
Tymur Buliekov
Ukraine
Local time: 16:28
Specializes in field
Native speaker of: Native in RussianRussian, Native in UkrainianUkrainian
PRO pts in category: 80
Grading comment
First validated answer (validated by peer agreement)

Peer comments on this answer (and responses from the answerer)
agree  Irina Panteleeva
8 hrs
agree  hawkwind
6 days
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Reference comments


1 hr
Reference

Reference information:
The Gradient (also called Slope) of a straight line shows how steep a straight line is. - https://www.mathsisfun.com/gradient.html
HomePublishingJournalsRSC Prospect
Gradient-elution chromatography
Definition: A separation method where the components are distributed between two phases, one of which is stationary, while the other moves in a definite direction (the 'mobile' phase). In gradient-elution chromatography the elution solvent strength of the mobile phase is gradually increased during the separation. https://www.rsc.org/publishing/journals/prospect/ontology.as...
Synonyms for slope - inclination - https://www.merriam-webster.com/thesaurus/slope


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Note added at 2 horas (2021-12-14 09:17:31 GMT)
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Slope (change in response per unit dose) - https://www.msdmanuals.com/en-pt/professional/clinical-pharm...
The hill slope equation used was used to fit dose-response curves: - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268638/
The slope factor (Hill slope) quantifies the steepness in the concentration response curve - file:///D:/Utilizador/Downloads/interlab%20comparison%20study%20of%20the%20cfe%20assay%20for%20assessing%20cytotoxicity%20of%20nms-pubsy%20jrc92910-20150224.pdf


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Note added at 2 horas (2021-12-14 09:23:53 GMT)
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Oral Slope Factor: 1 per mg/kg-day - https://iris.epa.gov/ChemicalLanding/&substance_nmbr=136

José Patrício
Portugal
Native speaker of: Native in PortuguesePortuguese
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