English to Russian Science Medical (general)

Typical """target trough serum concentration of L104EA29Y""" are between about 3µg/mL and about 30µg/mL over the first 3 to 6 months post-transplant which is sufficient to maintain function of the allograft, preferably between about 5µg/mL and about 20 µg/mL. Typically, """target trough serum concentration of L104EA29Y"""" during the maintenance phase are between about 0.2 µg/mL and about 3µg/mL, preferably between about 0.25µg/mL and about 2.5µg/mL.

The early phase regimen may range from the first 3 to 6 months post-transplantation and involves administration that initially is more frequent than monthly, preferably as frequently as daily, weekly or every two weeks depending on the immunologic risk and/or """target trough serum concentration""".

The method according to claim 1 or 2 wherein the costimulation blockade therapy is L104EA29YIg administered so to maintain a """target trough serum concentration""" between about 3µg/ml and about 30µg/ml.

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