English to Spanish Medical Medical: Cardiology

Buenas tardes,

¿Cómo se podría traducir "extensive" en estos dos casos? Es que no se si debería ser "extenso" o "significativo, importante".

Contextos:
- [...] a myocardial infarction in this system is most likely to produce extensive injury, with impairment of function, pulmonary congestion, and low output.
- In patients with extensive myocardial injury, coronary blood flow diminishes as cardiac output declines and heart rate accelerates.

Muchas gracias.